EFMC-ISMC 2022

XXVII EFMC International Symposium on Medicinal Chemistry

 Nice, France    September 4-8, 2022

Flash Poster Session 1 (FP01-FP10)

  • FP01    KOLOCOURIS    Antonios    UNIVERSITY OF ATHENS   
    NOVEL PYRAZOLO[3,4-C]PYRIDINE ANTAGONISTS WITH NANOMOLAR AFFINITY FOR A1 / A3 ADENOSINE RECEPTORS: BINDING KINETICS AND EXPLORATION OF THEIR BINDING PROFILE USING MUTAGENESIS EXPERIMENTS, MD SIMULATIONS AND  TI/MD CALCULATIONS

  • FP02    BHELA     Irene Preet    UNIVERSITY OF PIEMONTE   
    A STRAIGHTFORWARD SYNTHESIS OF PROTACS THROUGH MULTICOMPONENT REACTIONS

  • FP03    BOURGEAIS    Mathieu    UNIVERSITY OF BORDEAUX   
    BIFUNCTIONAL CHEMICAL TOOLS FOR THE TARGETED DEGRADATION OF FURIN

  • FP04    NOCE    Beatrice    UNIVERSITY OF ROME   
    NOVEL PYRIDINE-BASED HYDROXAMATES AND 2'-AMINOANILIDES AS HISTONE DEACETYLASE INHIBITORS: BIOCHEMICAL PROFILE AND ANTICANCER ACTIVITY

  • FP05    GRECO    Francesco Aleksy    GOETHE UNIVERSITY FRANKFURT   
    CHEMICAL EXPLORATION OF THE ORTHOSTERIC AND ALLOSTERIC POCKETS OF DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5 (MAP2K5/MEK5) BY SMALL MOLECULES

  • FP06    HUANG    Rong    PURDUE UNIVERSITY   
    RATIONAL DEVELOPMENT OF POTENT AND SPECIFIC INHIBITORS FOR METHYLTRANSFERASES

  • FP07    DRAKOPOULOS    Antonios    UNIVERSITY OF GOTHENBURG   
    EXPLORING THE MODE OF ACTION, THERMODYNAMIC PROFILE AND NUCLEOPHILE SELECTIVITY OF LABELLING WARHEADS FOR BRUTON'S TYROSINE KINASE

  • FP08    LOI    Elena    UNIVERSITY OF LJUBLJANA   
    THE QUEST FOR THE FIRST POTENT IN VIVO ACTING OGT INHIBITOR

  • FP09    PROJ    Matic    UNIVERSITY OF LJUBLJANA   
    REDOX ACTIVE OR THIOL REACTIVE? OPTIMIZATION OF RAPID SCREENS TO IDENTIFY LESS EVIDENT NUISANCE COMPOUNDS

  • FP10    KHEMAISSA    Sonia    SORBONNE UNIVERSITY   
    DESIGN AND INTERNALIZATION PROPERTIES OF CHIMERIC CPP-GAG BINDING PEPTIDES

Flash Poster Session 2 (FP11-FP20)

  • FP11    BERABEZ    Rayan    UNIVERSITY OF ORLEANS   
    SYNTHESIS AND PRECLINICAL VALIDATION OF LIMKS INHIBITORS: PROMISING DRUGS FOR OSTEOSARCOMA TREATMENT?

  • FP12    PAPANASTASIOU    Ioannis    UNIVERSITY OF ATHENS   
    AN OVERVIEW OF THE ANTITRYPANOSOMAL PROFILE OF ADAMANTANE SCAFFOLDS

  • FP13    RICCIO    Alessandra    UNIVERSITY OF PERUGIA   
    BEYOND CONVENTIONAL ANTI-CANCER AGENTS IN IMMUNOTHERAPY: HOW A TUMOR MICROENVIRONMENT LIMITATION COULD BE TURNED INTO AN ADVANTAGE

  • FP14     ESPELAND    Ludvik    UNIVERSITY OF BERGEN   
    TARGETING A PSEUDOMONAS AERUGINOSA beta-KETOACYL-(ACYL-CARRIER-PROTEIN) SYNTHASE WITH COVALENT INHIBITORS INSPIRED BY CERULENIN

  • FP15    GANTER     Benedikt     UNIVERSITY OF HAMBURG   
    SYNTHESIS OF MODIFIED T-1106-5´-TRIPHOSPHATES AS POTENTIAL INHIBITOR OF THE SARS-COV-2 RDRP

  • FP16    MARTIN SERRANO ORTIZ    Angela    UNIVERSITY OF GRENOBLE-ALPES   
    PRECLINICAL EVALUATION OF ANTIBODY RECRUITING GLYCODENDRIMERS (ARGs) FOR CANCER THERAPHY

  • FP17    ZOLLO    Michael    TU MUNICH   
    NEW CHEMOPROTEOMIC TECHNOLOGIES AND CHEMICAL MODALITIES FOR ANTIBIOTIC DISCOVERY

  • FP18     BRAUN    Maria    SPECS   
    DISCOVERY AND OPTIMIZATION OF NOVEL ANTI-INFECTIVES TARGETING ISPE USING PROTEIN-TEMPLATED SYNTHESIS

  • FP19    UGOLINI    Alessandra    ITALIAN INSTITUTE OF TECHNOLOGY   
    BACTERICIDAL AUTOPHAGY INHIBITORS TO TREAT RECURRENT INFECTIONS AND CANCER

  • FP20    KOVACHKA    Sandra    UNIVERSITY OF CÔTE D'AZUR   
    PANICEIN A HYDROQUINONE AND ANALOGS OVERCOME CHEMOTHERAPY RESISTANCE IN CANCER CELL


Flash Poster Session 3 (FP21-FP30)

  • FP21    TARKHANOVA    Olga    CHEMSPACE   
    ULTRA-LARGE CHEMICAL SPACES: APPROACHES TO BUILD AND EXPLORE

  • FP22     BARTOS    Piia    UNIVERSITY OF EASTERN FINLAND   
    THE DARK SIDE OF MOLECULAR DYNAMICS SIMULATIONS: RNA-PROTEIN COMPLEXES

  • FP23    DEGOTTE    Gilles    UNIVERSITY OF GRENOBLE-ALPES   
    DEVELOPMENT OF ENCODED COMBINATORIAL CHEMISTRY FOR THE IDENTIFICATION OF SPECIFIC LIGANDS OF G-QUADRUPLEX DNA STRUCTURES

  • FP24     COTMAN    Andrej Emanuel    UNIVERSITY OF LJUBLJANA   
    CHIRAL INDANS VIA DYNAMIC KINETIC RESOLUTION: THREE-DIMENSIONAL BUILDING BLOCKS AND NATURAL PRODUCTS

  • FP25    DINH    Le Vi    MONASH UNIVERSITY   
    DEVELOPMENT OF CALCIUM-SENSING RECEPTOR AGO-POSITIVE ALLOSTERIC MODULATORS, AC265347 DERIVATIVES, FOR THE TREATMENT OF HYPERPARATHYROIDISM AND RELATED DISORDERS

  • FP26    COLSON    Eloïse    UNIVERSITY OF BERNE   
    EXPANDING THE MEDICINAL CHEMISTRY SYNTHETIC TOOLBOX WITH A RADICAL [3+3]-ANNULATION TOWARDS TROPANE AND RELATED ALKALOID SKELETONS

  • FP27    MATVIYUK    Tatiana    ENAMINE   
    UNEXPECTED ISOMERIZATION OF OXETANE-CARBOXYLIC ACIDS

  • FP28    MORGAN    Barry    UNIVERSITY OF TEXAS   
    DOES DNA-ENCODED LIBRARY TECHNOLOGY PROVIDE "NOVELTY"?

  • FP29    MAKARA    Gergely    CHEMPASS   
    AI-ASSISTED GENERATIVE DESIGN OF SYNTHETICALLY FEASIBLE CHEMICAL SPACE FOR LEAD OPTIMIZATION

  • FP30    REP    Valentina    UNIVERSITY OF ZAGREB   
    NOVEL REVERSED AMIDINE BENZOTHIAZOLES: DESIGN, SYNTHESIS, ANTITRYPANOSOMAL ACTIVITY AND ADME PROFILING

Flash Poster Session 4 (FP31-FP40)

  • FP31    PALAFERRI    Leonardo    UZH   
    A RATIONAL AND SYSTEMATIC APPROACH TO PROTACS DEVELOPMENT: IDENTIFICATION OF CBP/EP300 DEGRADERS

  • FP32    CALZAFERRI    Francesco    CNRS   
    NOVEL STRATEGIES TO STUDY DNA METHYLATION IN HAEMATOLOGICAL CANCERS

  • FP33    MAPLE    Hannah    BIO-TECHNE   
    VALIDATING TARGETS FOR TARGETED PROTEIN DEGRADATION USING DTAG ? A COMPREHENSIVE WORKFLOW SOLUTION

  • FP34    GRISEL    Clément    CNRS  
    DESIGN OF CHEMICAL PROBES DERIVED FROM SCHWEINFURTHINS TO HIJACK OSBP

  • FP35    RAMOS LLORCA    Alba    UANTWERP   
    ACTIVITY-BASED PROBES TARGETING TRYPSIN-LIKE SERINE PROTEASES FOR TARGET AND BIOMARKER DISCOVERY

  • FP36    CORNER    Thomas    UNIVERSITY OF OXFORD   
    STRUCTURE-GUIDED OPTIMISATION OF SMALL-MOLECULE INHIBITORS OF THE HUMAN 2-OXOGLUTARATE-DEPENDENT OXYGENASE FACTOR INHIBITING HYPOXIA-INDUCIBLE FACTOR

  • FP37    CHIEW    Beatrice    UNIVERSITY OF NEWCASTLE   
    DESIGN IN THE DARK - ILLUMINATING THE DRUGGABILITY OF 53BP1 FOR BRCA-1 BREAST CANCER

  • FP38    BORLANDELLI    Valentina    LEIDEN UNIVERSITY   
    CYCLITOLS AS COVALENT INHIBITORS AND ACTIVITY-BASED PROBES FOR ?-D-GLUCURONIDASE AGAINST METABOLIC DRUG REACTIVATION AND CANCER PROGRESSION

  • FP39    VAN WIER    Suzanne    UNIVERSITY OF EAST ANGLIA   
    REMOVING CANCER'S IMMORTALITY: TARGETING TELOMERASE

  • FP40    VINAGREIRO    Carolina    LEIBNIZ INSTITUTE   
    ACTIVATABLE LUMINESCENT LANTHANOID PROBES FOR THE DETECTION OF VIRAL AND BACTERIAL INFECTIONS

Flash Poster Session 5 (FP41-FP50)

  • FP41    PROVENZANI    Riccardo    UNIVERSITY OF HELSINKI   
    MEMBRANE MOLECULAR DYNAMICS-ADJUVATED DESIGN AND SYNTHESIS OF MULTISUBSTITUTED PYRIDINES AS NOVEL PKC-TARGETED AGONISTS

  • FP42    ZWERGEL    Clemens    UNIVERSITY OF ROME LA SAPIENZA   
    NOVEL SELENIUM CONTAING COMPOUNDS AS A PROMISE IN CANCER THERAPY? ABCB1 EFFLUX PUMP MODULATING AGENTS WITH CYTOTOXIC AND ANTIPROLIFERATIVE ACTIONS IN RESISTANT T-LYMPHOMA

  • FP43    SHCHEHOLEVA    Iryna    UNIVERSITY OF COTE D'AZUR   
    ONCOGENIC MICRORNA INHIBITION BY SMALL MOLECULES: FRAGMENT-BASED DE NOVO LIGAND DESIGN AND SYNTHESIS

  • FP44    BOFFEY    Helen    ALBORADA DRUG DISCOVERY INSTITUTE   
    DEVELOPMENT OF SELECTIVE, BRAIN PENETRANT PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE GAMMA INHIBITORS WITH CONTRASTING BINDING MODES

  • FP45    NOZAL GARCIA    Vanesa    CIB - CSIC   
    RESCUING MOTOR NEURON DEGENERATION USING NOVEL MLK3 MODULATORS

  • FP46    KRAUPNER    Nicolas    UNIVERSITY OF LILLE   
    IDENTIFICATION AND HIT MODULATION OF INDOLE-BASED ACTIVATORS OF THE INSULIN DEGRADING ENZYME

  • FP47     KEIFF    Francois    LEIBNIZ INSITUTE   
    MODULATION OF THE MEISENHEIMER COMPLEX METABOLISM OF ANTIMYCOBACTERIAL BENZOTHIAZINONES

  • FP48    OTAVA    Tomáš    IOCB PRAGUE   
    DESIGN AND SYNTHESIS OF S-ADENOSYLHOMOCYSTEINE ANALOGUES AS NANOMOLAR INHIBITORS OF SARS-COV-2 NSP14 METHYLTRANSFERASE

  • FP49    LAPHOOKHIEO    Surat    MAE FAH LUANG UNIVERSITY   
    ALPHA-GLUCOSIDASE INHIBITORY ACTIVITY OF COMPOUNDS ISOLATED FROM FOUR ANNONACEAE PLANTS: DASYMASCHALON DASYMASCHALUM, DESMOS COCHINCHINESNSIS, POLYALTHIA CINNAMOMEA, AND TRIVALVARIA MACROPHYLLA

  • FP50    DROP    Marcin    JAGIELLONIAN UNIVERSITY   
    NOVEL 5-HT6R NEUTRAL ANTAGONISTS DERIVED FROM 2-ARYLPYRROLE: CONTRIBUTION OF AGONIST-ACTIVATED STATES OF THE RECEPTOR TO NEUROTOXICITY

Flash Poster Session 6 (FP51-FP60)

  • FP51    COLCHON-PIERNA    Esther    UNIVERSITY OF SANTIAGO DE COMPOSTELA   
    FREE LABELLING PLATFORM TO DETERMINE DRUG BINDING TO PROTEINS

  • FP52    JOCH    Melanie    LEIBNIZ INSTITUTE   
    A CELL-BASED METABOLIC ASSAY FOR HYDRIDE MEISENHEIMER FORMATION ASSESSMENT TO GUIDE LEAD OPTIMIZATION OF NEXT-GENERATION ANTITUBERCULAR BENZOTHIAZINONES

  • FP53    GENTILINI    Emilie    UNIVERSITY OF CÔTE D'AZUR   
    NOVEL METHODOLOGIES FOR THE SYNTHESIS OF POLYCYCLIC DERIVATIVES USING GOLD AND CARBOPHILIC METAL CATALYSIS

  • FP54    POCHET    Lionel    UNAMUR   
    TOWARDS NEW FXIIa INHIBITORS BY APPLICATION OF A FRAGMENT-BASED LEAD DISCOVERY APPROACH AND AFFINITY CAPILLARY ELECTROPHORESIS SCREENING ASSAY

  • FP55    NOWICKI    Krzysztof    WARSAW UNIVERSITY OF TECHNOLOGY     
    THE USE OF THIOL-FUNCTIONALIZED BENZOSILOXABOROLES FOR ACHIEVING DIVERSE SUBSTITUTION PATTERNS - BIOLOGICAL EVALUATION OF NOVEL PROMISING ANTIBACTERIAL AGENTS

  • FP56    LEBERECHT    Christoph    PHARMAI   
    GENERATION OF FOCUSED LIBRARIES: AI-POWERED REDUCTION OF LARGE COMPOUND LIBRARIES LEADS TO THE DISCOVERY OF NOVEL INHIBITORS OF SIRTUIN-1

  • FP57    MULLIRI    Kleni    UNIVERSITY OF BERN   
    SAR OF TRIQUINAZINE, A CLASS OF POTENT JANUS KINASE INHIBITORS

  • FP58    TARDIA    Piero     CHARLES RIVER LABORATORIES   
    DISCOVERY OF A NOVEL CLASS OF D-AMINO ACID OXIDASE INHIBITORS USING THE SCHRÖDINGER COMPUTATIONAL PLATFORM

  • FP59    SAN    Carine    CNAM   
    OPTIMIZATION OF A SYNTHETIC STEP USING A DESIGN OF EXPERIMENTS APPROACH: APPLICATION TO A LATE-STAGE RADIOLABELING METHOD BY ALUMINIUM-[18F]FLUORIDE COORDINATION

  • FP60    SCHEIBELBERGER    Lukas    UNIVERSITY OF VIENNA   
    SYNTHESIS OF 4-DEOXY-4-FLUORO-D-SEDOHEPTULOSE AND AN APPROACH FOR ITS FLUORINE-18 LABELED ANALOGUE