EFMC-ISMC 2021

XXVI EFMC International Symposium on Medicinal Chemistry

 Virtual Event    August 29-September 2, 2021

Award & Prize Lectures

THE NAUTA PHARMACOCHEMISTRY AWARD FOR MEDICINAL CHEMISTRY AND CHEMICAL BIOLOGY
Award Lecture

Prof. Ad P. IJZERMAN
Prof. Ad P. IJZERMAN
LEIDEN UNIVERSITY, Leiden, The Netherlands
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THE UCB-EHRLICH AWARD FOR EXCELLENCE IN MEDICINAL CHEMISTRY
Award Lecture

Dr Malin LEMURELL
Dr Malin LEMURELL
ASTRAZENECA, Gothenburg, Sweden
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THE IUPAC RICHTER PRIZE
The Discovery of Relpax® and Nurtec ODT® - Two Different Treatments for Migraine Headaches

Dr John E. MACOR
Dr John E. MACOR
SANOFI, Waltham, United States
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THE PROUS INSTITUTE-OVERTON AND MEYER AWARD FOR NEW TECHNOLOGIES IN DRUG DISCOVERY
Award Lecture

Prof. Gisbert SCHNEIDER
Prof. Gisbert SCHNEIDER
ETH ZÜRICH, Zürich, Switzerland

THE KLAUS GROHE AWARD
Award Lecture

Prof. Stephan A. SIEBER
Prof. Stephan A. SIEBER
TECHNICAL UNIVERSITY MUNICH, Garching, Germany
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Plenary Lectures

Translational Chemistry

Prof. Phil BARAN
Prof. Phil BARAN
THE SCRIPPS RESEARCH INSTITUTE, La Jolla, United States
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Title of talk be announced

Dr Karin BRINER
Dr Karin BRINER
NOVARTIS, Cambridge, United States

Medicinal Chemistry: More than Ever

Dr Jean-Paul CLOZEL
Dr Jean-Paul CLOZEL
IDORSIA PHARMACEUTICALS LTD, Allschwil, Switzerland
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Targeting Protein Scaffolding Function in Kinases

Prof. Stefan KNAPP
Prof. Stefan KNAPP
GOETHE UNIVERSITY FRANKFURT, Frankfurt am Main, Germany
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Invited Speakers

Innovative DNA-based Asymmetric Catalysis

Dr Stellios ARSENIYADIS
Dr Stellios ARSENIYADIS
QUEEN MARY UNIVERSITY OF LONDON, London, United Kingdom
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Chemical Biology of Antibody Conjugates and Natural Products

Prof. Gonçalo BERNARDES
Prof. Gonçalo BERNARDES
UNIVERSITY OF CAMBRIDGE, Cambridge, United Kingdom
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Omics-Based Development of Nanomedicines for Safe and Effective Drug Delivery in Cancer

Prof. Erem BILENSOY
Prof. Erem BILENSOY
HACETTEPE UNIVERSITY, Ankara, Turkey
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Utilization of Fe/α-Ketoglutarate-Dependent Enzymes for C-H Functionalization

Prof. Rebecca BULLER
Prof. Rebecca BULLER
ZHAW SCHOOL OF LIFE SCIENCES AND FACILITY MANAGEMENT, Wädenswil, Switzerland
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From Phenotypes to Molecular Targets to Mechanistic Pathways

Dr Paola CASTALDI
Dr Paola CASTALDI
LIFEMINE THERAPEUTICS, Cambridge, United States
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Title of talk to be confirmed

Dr Hugo CEULEMANS
Dr Hugo CEULEMANS
JANSSEN PHARMACEUTICA, Brussels, Belgium

Title tbc

Grace CHUANG
CYTOKINETICS, South San Francisco, United States

New Examples for N-Hydroxyamidine Prodrugs

Prof. Bernd CLEMENT
Prof. Bernd CLEMENT
UNIVERSITY OF KIEL, Kiel, Germany
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Exploring Chemical Reactivity with an AI-Driven Chemputer

Prof. Leroy CRONIN
Prof. Leroy CRONIN
UNIVERSITY OF GLASGOW, Glasgow, United Kingdom
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Inhaled New Modalities in Respiratory Disease: Past, Present, Future

Dr Werngard CZECHTIZKY
Dr Werngard CZECHTIZKY
ASTRAZENECA, Mölndal, Sweden
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Therapies for Gram-Negative Bacterial Infections: New Approaches and Further Generations of Existing Series

Dr Mike DAWSON
Dr Mike DAWSON
MIKE DAWSON ANTIMICROBIAL RESEARCH CONSULTANCY LTD., Stevenage, United Kingdom
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A Chemical Approach to Controlling Cell Fate

Dr Sheng DING
Dr Sheng DING
UNIVERSITY OF CALIFORNIA SAN FRANCISCO, San Francisco, United States
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Novel Molecular Targets for the Treatment of Fibrosis

Prof. Joerg DISTLER
Prof. Joerg DISTLER
UNIVERSITY OF ERLANGEN–NUREMBERG, Erlangen, Germany
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The Discovery of a Novel Inhaled PI3Kd Inhibitor by Lung Retention Optimisation

Ms Montse ERRA SOLA
Ms Montse ERRA SOLA
ALMIRALL, S.A., Barcelona, Spain
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Understanding Immune Cell Interactions via Photocatalysis

Dr Niyi FADEYI
Dr Niyi FADEYI
MERCK & CO, Cambridge, United States
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Discovery and Disclosure of GLPG1205, a First in Class GPR84 Negative Allosteric Modulator in Phase II Clinical Trial

Dr Romain GOSMINI
Dr Romain GOSMINI
GALAPAGOS, Romainville, France
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Drugging RNA Modifying Enzymes

Dr David HARDICK
Dr David HARDICK
STORM THERAPEUTICS LTD, Cambridge, United Kingdom

Title of talk to be confirmed

Dr Gerhard HESSLER
Dr Gerhard HESSLER
SANOFI-AVENTIS DEUTSCHLAND, Frankfurt am Main, Germany

Reprogramming Nonribosomal Biosynthesis

Prof. Donald HILVERT
Prof. Donald HILVERT
ETH ZURICH, ZURICH, Switzerland
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Lectins from Pathogens: From Structural Glycobiology to Antiadhesive Strategies

Dr Anne IMBERTY
Dr Anne IMBERTY
CNRS/CERMAV, Grenoble, France
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AI Assisted and Automated Chemical Synthesis

Prof. Klavs F. JENSEN
Prof. Klavs F. JENSEN
MASSACHUSETTS INSTITUTE OF TECHNOLOGY, Cambridge, United States
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Discovery of a Novel Class of Small Molecule Dengue Virus Inhibitors

Dr Tim JONCKERS
Dr Tim JONCKERS
JANSSEN, Beerse, Belgium
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Structure-Based Optimization and Synthesis of M3258, a Potent and Selective Inhibitor of the Immunoproteasome Subunit LMP7 (beta5i) Demonstrating Strong Efficacy in Multiple Myeloma Models

Dr Markus KLEIN
Dr Markus KLEIN
MERCK KGAA, Darmstadt, Germany
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Title of talk to be confirmed

Prof. Cheng LUO
SHANGHAI INSTITUTE OF MATERIA MEDICA, Shanghai, China

Identification of Potent and Long Acting Single-Chain Peptide Mimetics of Human Relaxin-2 for Cardiovascular Diseases

Dr Sergio MALLART
Dr Sergio MALLART
SANOFI R&D, CHILLY MAZARIN, France
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Living in the World of RNA Therapeutics using Biomimetic Chemistry

Dr Muthiah MANOHARAN
Dr Muthiah MANOHARAN
ALNYLAM PHARMACEUTICALS, Cambridge, United States
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Tethered Peptide Macrocycles, a Novel Antibiotic Class Targeting Acinetobacter Baumannii

Dr Patrizio MATTEI
Dr Patrizio MATTEI
ROCHE INNOVATION CENTER BASEL, Basel, Switzerland
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Neladenoson Bialanate Hydrochloride: A Prodrug of a Partial Adenosine A1 Receptor Agonist

Dr Daniel MEIBOM
Dr Daniel MEIBOM
BAYER PHARMA, Wuppertal, Germany
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Bioorganic Synthesis – Adventures at the Chemistry/Biology Interface

Prof. Marko D. MIHOVILOVIC
Prof. Marko D. MIHOVILOVIC
TU WIEN, Vienna, Austria
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Allosteric Regulation of GTP Cyclohydrolase I

Dr Herbert NAR
Dr Herbert NAR
BOEHRINGER INGELHEIM, Biberach, Germany
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Antibody-Drug Conjugates (ADCs) and Small Molecule-Drug Conjugates (SMDCs): a Direct Comparison

Prof. Dario NERI
Prof. Dario NERI
ETH ZÜRICH, Zürich, Switzerland
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MAP4K4 Inhibitors for the Treatment of Myocardial Infarction

Dr Gary NEWTON
Dr Gary NEWTON
THE INSTITUTE OF CANCER RESEARCH, London , United Kingdom
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Design, Synthesis, and Development of Lectin Ligand Mimetics

Prof. Ulf NILSSON
Prof. Ulf NILSSON
LUND UNIVERSITY, Lund, Sweden
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Sensing Enzymatic Reactions with Quantum Dots

Dr Valle PALOMO
Dr Valle PALOMO
CENTRO DE INVESTIGACIONES BIOLÓGICAS-CSIC, Madrid, Spain
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Antivirals Against Chikungunya Virus: Analyzing the Current Situation to Identify New Opportunities

Prof. Maria-Jesus PÉREZ-PÉREZ
Prof. Maria-Jesus PÉREZ-PÉREZ
INSTITUTO DE QUÍMICA MÉDICA, Madrid, Spain
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Drugging mRNA with Drug-like Small Molecules

Dr Jennifer PETTER
Dr Jennifer PETTER
ARRAKIS THERAPEUTICS, Waltham, United States
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The Design, Synthesis and Optimization of αvβ6 Antagonists as Potential Idiopathic Pulmonary Fibrosis Agents

Dr Jonathan PHILLIPS
AMGEN, Newbury Park, United States

Proteomes in 3D

Prof. Paola PICOTTI
Prof. Paola PICOTTI
ETH ZÜRICH, Zürich, Switzerland
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Magic in the Moonlight: Our Contribution to the Development of IDO1 Inhibitors for Cancer Immunotherapy

Prof. Tracey PIRALI
Prof. Tracey PIRALI
UNIVERSITÀ DEL PIEMONTE ORIENTALE, Novara, Italy
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C-type Lectin Receptors as Drug Targets

Dr Christoph RADEMACHER
Dr Christoph RADEMACHER
UNIVERSITY OF VIENNA, Vienna, Austria
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Targeting Cancer

Prof. Daniel RAUH
Prof. Daniel RAUH
TU DORTMUND, Dortmund, Germany
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Prodrug Strategies in Medicinal Chemistry

Prof. Jarkko RAUTIO
Prof. Jarkko RAUTIO
UNIVERSITY OF EASTERN FINLAND, Kuopio, Finland
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The Role of Cryo-EM in Fragment-Based Drug Discovery

Dr Judith REEKS
Dr Judith REEKS
ASTEX PHARMACEUTICALS, Cambridge, United Kingdom
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Single-Molecule Imaging in Live Cells

Prof. Pablo RIVERA FUENTES
Prof. Pablo RIVERA FUENTES
EPF LAUSANNE, Lausanne, Switzerland
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Discovery of Small Molecules to Manipulate Cell Fate in vivo: Towards New Therapies for Degenerative Diseases

Prof. Angela RUSSELL
Prof. Angela RUSSELL
UNIVERSITY OF OXFORD, Oxford, United Kingdom
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Augmenting Drug Hunters with Generative Chemistry Models

Dr Nadine SCHNEIDER
Dr Nadine SCHNEIDER
NOVARTIS, Basel, Switzerland
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Photopharmacology: Towards Light-Controlled Therapy

Dr Wiktor SZYMANSKI
Dr Wiktor SZYMANSKI
UNIVERSITY OF GRONINGEN, Groningen, The Netherlands
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Chemical Probes to Study Lipid Signaling

Dr Mario VAN DER STELT
Dr Mario VAN DER STELT
LEIDEN UNIVERSITY, Leiden, The Netherlands
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Scaffold-Assisted Peptide Cyclizations: Towards Protein Mimics

Prof. Jan VAN MAARSEVEEN
Prof. Jan VAN MAARSEVEEN
UNIVERSITY OF AMSTERDAM, Amsterdam, The Netherlands
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NLRP3 inflammasome inhibitors for Inflammatory and Neuroinflammatory Disease

Dr Alan WATT
Dr Alan WATT
NODTHERA, Little Chesterford, United Kingdom
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Chemical Probes to Explore Cancer Biology and Validate Drug Targets

Prof. Paul WORKMAN
Prof. Paul WORKMAN
INSTITUTE OF CANCER RESEARCH, London, United Kingdom
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Development of Fluorinated PET Tracers for Imaging of α1 Receptors in the Brain

Prof. Bernhard WÜNSCH
Prof. Bernhard WÜNSCH
UNIVERSITY OF MÜNSTER, Münster, Germany
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Drug R&D Targeting Cell Necrosis

Prof. Shengyong YANG
Prof. Shengyong YANG
SICHUAN UNIVERSITY, Sichuan, China
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Allosteric Modulator Discovery: from Method Development to Applications

Prof. Jian ZHANG
Prof. Jian ZHANG
SHANGHAI JIAO TONG UNIVERSITY, Shanghai, China
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