RICT 2019
Conferences > Archives > RICT 2019
Wednesday July 3, 2019
07:30Registration
08:30RICT 2019 Opening
Prof. Sebastien PAPOT (SCT & UNIVERSITY OF POITIERS, Poitiers, France)
Prof. Pascal MARCHAND (UNIVERSITY OF NANTES, Nantes, France)
Dr Patricia LEMARCHAND (UNIVERSITY OF NANTES, Nantes, France)
Inaugural Conference
Session Chair:
Prof. Sebastien PAPOT
(SCT & UNIVERSITY OF POITIERS, Poitiers, France)
09:00PL01: What Makes a Great Medicinal Chemist: Some Fresh Thoughts
Dr Mark MURCKO
(RELAY THERAPEUTICS, Boston, United States)
Session 1: Recent Advances for Cancer Therapy
Session Chair:
Dr Yannick JACQUES
(INSERM/CNRS, Nantes, France)
09:45PL02: Reprogramming the Reactivity of Iron in Cancer
Dr Raphaël RODRIGUEZ
(INSTITUT CURIE, Paris, France)
10:30Coffee Break and Exhibition
11:00PL03: Quo Vadis Small Molecule Cancer Therapeutics?
Dr Ingo HARTUNG
(BAYER HEALTHCARE, Darmstadt, Germany)
11:45KL01: Therapeutic Potential of Macrocyclic ALK2 Inhibitors
Dr Pascal BENDERITTER
(ONCODESIGN, Dijon, France)
12:15Lunch
13:00Posters (Odd numbers) and Exhibition
Session 2: Artificial Intelligence in Drug Discovery
Session Chair:
Prof. Pascal BONNET
(UNIVERSITY OF ORLÉANS, Orléans, France)
14:30PL04: Massively Multi-target Profile-QSAR: IC50 Predictions Comparable to 4-Concentration Experiments for most Novartis Assays
Dr Eric MARTIN
(NOVARTIS, Emeryville, United States)
15:15PL05: Automated Syntheses Planning and its Implications for Drug Design
Dr Marwin SEGLER
(BENEVOLENTAI, Cambridge, United Kingdom)
16:00Coffee Break and Exhibition
Session 3: Mechanism Based Approaches
Session Chair:
Dr Maria DUCA
(UNIVERSITY OF CÔTE D'AZUR, Nice, France)
16:30PL06: Discovery of Risdiplam, a Selective Survival of Motor Neuron-2 (SMN2) Gene Splicing Modifier for the Treatment of Spinal Muscular Atrophy (SMA)
Dr Hasane RATNI
(F. HOFFMANN-LA ROCHE LTD, Basel , Switzerland)
17:15PL07: The Influence of Free Ligand Conformations on Mcl-1 PPI Inhibition
Dr Rodrigo CARBAJO
(ASTRAZENECA, Cambridge, United Kingdom)
18:00KL02: Tackling a Unique S1 Protease by SBDD - Highly Potent & Selective Factor D Inhibitors - Age-Related Macular Generation (AMD)
Dr Edwige LORTHIOIS
(NOVARTIS, Basel, Switzerland)
18:30Welcome and Networking Reception
20:30End of the day
Thursday July 4, 2019
Session 4: Paul Ehrlich Award Lecture (sponsored by Janssen Research & Development)
Session Chairs:
Dr Luc VAN HIJFTE (MERCACHEMSYNCOM, Nijmegen, The Netherlands)
Dr Jose CID (JANSSEN R&D, Toledo, Spain)
08:45PL08: Paul Ehrlich Award Lecture - Chemotype - Phenotype - Target
Prof. Herbert WALDMANN
(MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY, Dortmund, Germany)
Session 5: New Breakthrough in Antibody-based Therapy
Session Chair:
Prof. Marie-Claude VIAUD-MASSUARD
(FACULTÉ DES SCIENCES PHARMACEUTIQUES - UNIVERSITÉ DE TOURS, TOURS, France)
09:45PL09: Chemical Physiology of Antibody Conjugates and Natural Products
Prof. Gonçalo BERNARDES
(INSTITUTO DE MEDICINA MOLECULAR, PORTUGAL & UNIVERSITY OF CAMBRIDGE, Cambridge, United Kingdom)
10:30Coffee Break and Exhibition
11:00PL10: Click-Cleavable Antibody-Drug Conjugates
Dr Marc ROBILLARD
(TAGWORKS PHARMACEUTICALS, Eindhoven, The Netherlands)
11:45PL11: Increasing Brain Exposure of Therapeutic Antibodies
Dr Dominique LESUISSE
(SCT & SANOFI, Chilly-Mazarin, France)
12:30Lunch
13:00Posters (Even numbers) and Exhibition
Session 6: Sugars in Drug Discovery
Session Chair:
Prof. Didier DUBREUIL
(CEISAM - UNIVERSITY OF NANTES, Nantes, France)
14:30PL12: Carbohydrate-Lectin Interactions - What Makes Them Unique?
Prof. Dr Beat ERNST
(UNIVERSITY OF BASEL, Basel, Switzerland)
15:15PL13: Complex Glycans in Health and Disease
Prof. Geert-Jan BOONS
(UTRECHT UNIVERSITY, Utrecht, The Netherlands)
16:00Coffee Break and Exhibition
Session 7: New Modalities in Drug Discovery
Session Chair:
Prof. Pascal MARCHAND
(UNIVERSITY OF NANTES, Nantes, France)
16:30PL14: Unlocking Drug Discovery Power through Collaborative Efforts between Academia and CRO : Bringing Novel Tankyrase Inhibitors towards the Clinic
Dr Anita WEGERT
(MERCACHEM-SYNCOM, Nijmegen, The Netherlands)
17:15PL15: Identification of S 64315, a Potent and Selective Mcl-1 Inhibitor through Fragment-based Drug Discovery
Dr Andras KOTSCHY
(SERVIER RESEARCH INSTITUTE OF MEDICINAL CHEMISTRY, Budapest, Hungary)
18:00KL03: Nanofitin Modules Platform: Go Multispecific, Go Multiparatopic !
Dr Anne CHEVREL
(AFFILOGIC, Nantes, France)
18:30End of the day
20:30Banquet
Friday July 5, 2019
Session 8: New Tools for Therapeutic Innovation
Session Chair:
Prof. Joachim JOSE
(UNIVERSITY OF MÜNSTER, Münster, Germany)
08:30PL16: Straightforward Conversion of Peptides into Bioactive Lactam-Based Foldamers
Prof. Muriel AMBLARD
(CNRS-UNIVERSTY OF MONTPELLIER I, Montpellier, France)
09:15PL17: Chemical Biology of mRNA Modifications
Prof. Andrea RENTMEISTER
(UNIVERSITY OF MÜNSTER, Münster, Germany)
10:00Coffee Break and Exhibition
Session 9: Modifying Proteins Structures and Functions
Session Chair:
Dr Gilles GUICHARD
(UNIVERSITY OF BORDEAUX, Pessac, France)
10:30PL18: Modulating Different Components of the Ubiquitin System with Small Molecules and Cyclic Peptides
Prof. Ashraf BRIK
(TECHNION-ISRAEL INSTITUTE OF TECHNOLOGY, Haifa, Israel)
11:15PL19: Cysteine Arylation to Engineer, Deliver, and Discover Proteins
Prof. Bradley Lether PENTELUTE
(MASSACHUSETTS INSTITUTE OF TECHNOLOGY, Cambridge, MA, United States)
Session 10: Pierre Fabre Award Lecture (Sponsored by Pierre Fabre)
Session Chairs:
Dr Serge GRISONI (CENTRE DE RECHERCHE ET DÉVELOPPEMENT PIERRE FABRE, Toulouse, France)
Dr Brigitte LESUR (SCT & INSTITUT DE RECHERCHES SERVIER, Paris, France)
12:00PL20: Pierre Fabre Award Lecture - Click Chemistry with Mesoionics: New Tools for Chemical Biology
Dr Frédéric TARAN
(CEA/SACLAY, Gif-sur-Yvette, France)
13:00Closing Remarks

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