| Wednesday July 3, 2019 |
| 07:30 | Registration |
|
| 08:30 | RICT 2019 Opening |
Prof. Sebastien PAPOT (UNIVERSITY OF POITIERS, Poitiers, France)
Prof. Pascal MARCHAND (UNIVERSITY OF NANTES, Nantes, France)
Dr Patricia LEMARCHAND (UNIVERSITY OF NANTES, Nantes, France) |
| Inaugural Conference |
|
| Session Chair: |
Prof. Sebastien PAPOT
(UNIVERSITY OF POITIERS, Poitiers, France) |
| 09:00 | PL01: What Makes a Great Medicinal Chemist: Some Fresh Thoughts |
Dr Mark MURCKO
(RELAY THERAPEUTICS, Holliston, United States) |
| Session 1: Recent Advances for Cancer Therapy |
|
| Session Chair: |
Dr Yannick JACQUES
(INSERM/CNRS, Nantes, France) |
| 09:45 | PL02: Reprogramming the Reactivity of Iron in Cancer |
Dr Raphaël RODRIGUEZ
(INSTITUT CURIE, Paris, France) |
| 10:30 | Coffee Break and Exhibition |
|
| 11:00 | PL03: Quo Vadis Small Molecule Cancer Therapeutics? |
Dr Ingo HARTUNG
(BAYER HEALTHCARE, Darmstadt, Germany) |
| 11:45 | KL01: Therapeutic Potential of Macrocyclic ALK2 Inhibitors |
Dr Pascal BENDERITTER
(ONCODESIGN, Dijon, France) |
| 12:15 | Lunch |
|
| 13:00 | Posters (Odd numbers) and Exhibition |
|
| Session 2: Artificial Intelligence in Drug Discovery |
|
| Session Chair: |
Prof. Pascal BONNET
(UNIVERSITY OF ORLÉANS, Orléans, France) |
| 14:30 | PL04: Massively Multi-target Profile-QSAR: IC50 Predictions Comparable to 4-Concentration Experiments for most Novartis Assays |
Dr Eric MARTIN
(NOVARTIS, Emeryville, United States) |
| 15:15 | PL05: Automated Syntheses Planning and its Implications for Drug Design |
Dr Marwin SEGLER
(BENEVOLENTAI, Cambridge, United Kingdom) |
| 16:00 | Coffee Break and Exhibition |
|
| Session 3: Mechanism Based Approaches |
|
| Session Chair: |
Dr Maria DUCA
(UNIVERSITY OF CÔTE D'AZUR, Nice, France) |
| 16:30 | PL06: Discovery of Risdiplam, a Selective Survival of Motor Neuron-2 (SMN2) Gene Splicing Modifier for the Treatment of Spinal Muscular Atrophy (SMA) |
Dr Hasane RATNI
(F. HOFFMANN-LA ROCHE LTD, Basel , Switzerland) |
| 17:15 | PL07: The Influence of Free Ligand Conformations on Mcl-1 PPI Inhibition |
Dr Rodrigo CARBAJO
(ASTRAZENECA, Cambridge, United Kingdom) |
| 18:00 | KL02: Tackling a Unique S1 Protease by SBDD - Highly Potent & Selective Factor D Inhibitors - Age-Related Macular Generation (AMD)
|
Dr Edwige LORTHIOIS
(NOVARTIS, Basel, Switzerland) |
| 18:30 | Welcome and Networking Reception |
|
| 20:30 | End of the day |
|
| Thursday July 4, 2019 |
| Session 4: Paul Ehrlich Award Lecture (sponsored by Janssen Research & Development) |
|
| Session Chairs: |
Dr Luc VAN HIJFTE (MERCACHEMSYNCOM, Nijmegen, The Netherlands)
Dr Jose CID (JANSSEN R&D, Toledo, Spain) |
| 08:45 | PL08: Paul Ehrlich Award Lecture - Chemotype - Phenotype - Target
|
Prof. Herbert WALDMANN
(MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY, Dortmund, Germany) |
| Session 5: New Breakthrough in Antibody-based Therapy |
|
| Session Chair: |
Prof. Marie-Claude VIAUD-MASSUARD
(FACULTÉ DES SCIENCES PHARMACEUTIQUES - UNIVERSITÉ DE TOURS, TOURS, France) |
| 09:45 | PL09: Chemical Physiology of Antibody Conjugates and Natural Products |
Prof. Gonçalo BERNARDES
(INSTITUTO DE MEDICINA MOLECULAR, PORTUGAL & UNIVERSITY OF CAMBRIDGE, Cambridge, United Kingdom) |
| 10:30 | Coffee Break and Exhibition |
|
| 11:00 | PL10: Click-Cleavable Antibody-Drug Conjugates |
Dr Marc ROBILLARD
(TAGWORKS PHARMACEUTICALS, Eindhoven, The Netherlands) |
| 11:45 | PL11: Increasing Brain Exposure of Therapeutic Antibodies |
Dr Dominique LESUISSE
(SCT & SANOFI, Chilly-Mazarin, France) |
| 12:30 | Lunch |
|
| 13:00 | Posters (Even numbers) and Exhibition |
|
| Session 6: Sugars in Drug Discovery |
|
| Session Chair: |
Prof. Didier DUBREUIL
(CEISAM - UNIVERSITY OF NANTES, Nantes, France) |
| 14:30 | PL12: Carbohydrate-Lectin Interactions - What Makes Them Unique? |
Prof. Dr Beat ERNST
(UNIVERSITY OF BASEL, Basel, Switzerland) |
| 15:15 | PL13: Complex Glycans in Health and Disease |
Prof. Geert-Jan BOONS
(UTRECHT UNIVERSITY, Utrecht, The Netherlands) |
| 16:00 | Coffee Break and Exhibition |
|
| Session 7: New Modalities in Drug Discovery |
|
| Session Chair: |
Prof. Pascal MARCHAND
(UNIVERSITY OF NANTES, Nantes, France) |
| 16:30 | PL14: Unlocking Drug Discovery Power through Collaborative Efforts between Academia and CRO : Bringing Novel Tankyrase Inhibitors towards the Clinic |
Dr Anita WEGERT
(MERCACHEM-SYNCOM, Nijmegen, The Netherlands) |
| 17:15 | PL15: Identification of S 64315, a Potent and Selective Mcl-1 Inhibitor through Fragment-based Drug Discovery |
Dr Andras KOTSCHY
(SERVIER RESEARCH INSTITUTE OF MEDICINAL CHEMISTRY, Budapest, Hungary) |
| 18:00 | KL03: Nanofitin Modules Platform: Go Multispecific, Go Multiparatopic ! |
Dr Anne CHEVREL
(AFFILOGIC, Nantes, France) |
| 18:30 | End of the day |
|
| 20:30 | Banquet |
|
| Friday July 5, 2019 |
| Session 8: New Tools for Therapeutic Innovation |
|
| Session Chair: |
Prof. Joachim JOSE
(UNIVERSITY OF MÜNSTER, Münster, Germany) |
| 08:30 | PL16: Straightforward Conversion of Peptides into Bioactive Lactam-Based Foldamers |
Prof. Muriel AMBLARD
(CNRS-UNIVERSTY OF MONTPELLIER I, Montpellier, France) |
| 09:15 | PL17: Chemical Biology of mRNA Modifications |
Prof. Andrea RENTMEISTER
(UNIVERSITY OF MÜNSTER, Münster, Germany) |
| 10:00 | Coffee Break and Exhibition |
|
| Session 9: Modifying Proteins Structures and Functions |
|
| Session Chair: |
Dr Gilles GUICHARD
(UNIVERSITY OF BORDEAUX, Bordeaux, France) |
| 10:30 | PL18: Modulating Different Components of the Ubiquitin System with Small Molecules and Cyclic Peptides |
Prof. Ashraf BRIK
(TECHNION-ISRAEL INSTITUTE OF TECHNOLOGY, Haifa, Israel) |
| 11:15 | PL19: Cysteine Arylation to Engineer, Deliver, and Discover Proteins |
Prof. Bradley Lether PENTELUTE
(MASSACHUSETTS INSTITUTE OF TECHNOLOGY, Cambridge, MA, United States) |
| Session 10: Pierre Fabre Award Lecture (Sponsored by Pierre Fabre) |
|
| Session Chairs: |
Dr Serge GRISONI (CENTRE DE RECHERCHE ET DÉVELOPPEMENT PIERRE FABRE, Toulouse, France)
Dr Brigitte LESUR (SCT & INSTITUT DE RECHERCHES SERVIER, Paris, France) |
| 12:00 | PL20: Pierre Fabre Award Lecture - Click Chemistry with Mesoionics: New Tools for Chemical Biology |
Dr Frédéric TARAN
(CEA/SACLAY, Gif-sur-Yvette, France) |
| 13:00 | Closing Remarks |
|
