Wednesday July 3, 2019 |
07:30 | Registration |
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08:30 | RICT 2019 Opening |
Prof. Sebastien PAPOT (UNIVERSITY OF POITIERS, Poitiers, France) Prof. Pascal MARCHAND (UNIVERSITY OF NANTES, Nantes, France) Dr Patricia LEMARCHAND (UNIVERSITY OF NANTES, Nantes, France) |
| Inaugural Conference |
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| Session Chair: |
Prof. Sebastien PAPOT (UNIVERSITY OF POITIERS, Poitiers, France) |
09:00 | PL01: What Makes a Great Medicinal Chemist: Some Fresh Thoughts |
Dr Mark MURCKO (RELAY THERAPEUTICS, Holliston, United States) |
| Session 1: Recent Advances for Cancer Therapy |
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| Session Chair: |
Dr Yannick JACQUES (INSERM/CNRS, Nantes, France) |
09:45 | PL02: Reprogramming the Reactivity of Iron in Cancer |
Dr Raphaël RODRIGUEZ (INSTITUT CURIE, Paris, France) |
10:30 | Coffee Break and Exhibition |
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11:00 | PL03: Quo Vadis Small Molecule Cancer Therapeutics? |
Dr Ingo HARTUNG (BAYER HEALTHCARE, Darmstadt, Germany) |
11:45 | KL01: Therapeutic Potential of Macrocyclic ALK2 Inhibitors |
Dr Pascal BENDERITTER (ONCODESIGN, Dijon, France) |
12:15 | Lunch |
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13:00 | Posters (Odd numbers) and Exhibition |
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| Session 2: Artificial Intelligence in Drug Discovery |
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| Session Chair: |
Prof. Pascal BONNET (UNIVERSITY OF ORLÉANS, Orléans, France) |
14:30 | PL04: Massively Multi-target Profile-QSAR: IC50 Predictions Comparable to 4-Concentration Experiments for most Novartis Assays |
Dr Eric MARTIN (NOVARTIS, Emeryville, United States) |
15:15 | PL05: Automated Syntheses Planning and its Implications for Drug Design |
Dr Marwin SEGLER (BENEVOLENTAI, Cambridge, United Kingdom) |
16:00 | Coffee Break and Exhibition |
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| Session 3: Mechanism Based Approaches |
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| Session Chair: |
Dr Maria DUCA (UNIVERSITY OF CÔTE D'AZUR, Nice, France) |
16:30 | PL06: Discovery of Risdiplam, a Selective Survival of Motor Neuron-2 (SMN2) Gene Splicing Modifier for the Treatment of Spinal Muscular Atrophy (SMA) |
Dr Hasane RATNI (F. HOFFMANN-LA ROCHE LTD, Basel , Switzerland) |
17:15 | PL07: The Influence of Free Ligand Conformations on Mcl-1 PPI Inhibition |
Dr Rodrigo CARBAJO (ASTRAZENECA, Cambridge, United Kingdom) |
18:00 | KL02: Tackling a Unique S1 Protease by SBDD - Highly Potent & Selective Factor D Inhibitors - Age-Related Macular Generation (AMD)
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Dr Edwige LORTHIOIS (NOVARTIS, Basel, Switzerland) |
18:30 | Welcome and Networking Reception |
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20:30 | End of the day |
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Thursday July 4, 2019 |
| Session 4: Paul Ehrlich Award Lecture (sponsored by Janssen Research & Development) |
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| Session Chairs: |
Dr Luc VAN HIJFTE (MERCACHEMSYNCOM, Nijmegen, The Netherlands) Dr Jose CID (JANSSEN R&D, Toledo, Spain) |
08:45 | PL08: Paul Ehrlich Award Lecture - Chemotype - Phenotype - Target
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Prof. Herbert WALDMANN (MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY, Dortmund, Germany) |
| Session 5: New Breakthrough in Antibody-based Therapy |
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| Session Chair: |
Prof. Marie-Claude VIAUD-MASSUARD (FACULTÉ DES SCIENCES PHARMACEUTIQUES - UNIVERSITÉ DE TOURS, TOURS, France) |
09:45 | PL09: Chemical Physiology of Antibody Conjugates and Natural Products |
Prof. Gonçalo BERNARDES (INSTITUTO DE MEDICINA MOLECULAR, PORTUGAL & UNIVERSITY OF CAMBRIDGE, Cambridge, United Kingdom) |
10:30 | Coffee Break and Exhibition |
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11:00 | PL10: Click-Cleavable Antibody-Drug Conjugates |
Dr Marc ROBILLARD (TAGWORKS PHARMACEUTICALS, Eindhoven, The Netherlands) |
11:45 | PL11: Increasing Brain Exposure of Therapeutic Antibodies |
Dr Dominique LESUISSE (SCT & SANOFI, Chilly-Mazarin, France) |
12:30 | Lunch |
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13:00 | Posters (Even numbers) and Exhibition |
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| Session 6: Sugars in Drug Discovery |
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| Session Chair: |
Prof. Didier DUBREUIL (CEISAM - UNIVERSITY OF NANTES, Nantes, France) |
14:30 | PL12: Carbohydrate-Lectin Interactions - What Makes Them Unique? |
Prof. Dr Beat ERNST (UNIVERSITY OF BASEL, Basel, Switzerland) |
15:15 | PL13: Complex Glycans in Health and Disease |
Prof. Geert-Jan BOONS (UTRECHT UNIVERSITY, Utrecht, The Netherlands) |
16:00 | Coffee Break and Exhibition |
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| Session 7: New Modalities in Drug Discovery |
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| Session Chair: |
Prof. Pascal MARCHAND (UNIVERSITY OF NANTES, Nantes, France) |
16:30 | PL14: Unlocking Drug Discovery Power through Collaborative Efforts between Academia and CRO : Bringing Novel Tankyrase Inhibitors towards the Clinic |
Dr Anita WEGERT (MERCACHEM-SYNCOM, Nijmegen, The Netherlands) |
17:15 | PL15: Identification of S 64315, a Potent and Selective Mcl-1 Inhibitor through Fragment-based Drug Discovery |
Dr Andras KOTSCHY (SERVIER RESEARCH INSTITUTE OF MEDICINAL CHEMISTRY, Budapest, Hungary) |
18:00 | KL03: Nanofitin Modules Platform: Go Multispecific, Go Multiparatopic ! |
Dr Anne CHEVREL (AFFILOGIC, Nantes, France) |
18:30 | End of the day |
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20:30 | Banquet |
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Friday July 5, 2019 |
| Session 8: New Tools for Therapeutic Innovation |
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| Session Chair: |
Prof. Joachim JOSE (UNIVERSITY OF MÜNSTER, Münster, Germany) |
08:30 | PL16: Straightforward Conversion of Peptides into Bioactive Lactam-Based Foldamers |
Prof. Muriel AMBLARD (CNRS-UNIVERSTY OF MONTPELLIER I, Montpellier, France) |
09:15 | PL17: Chemical Biology of mRNA Modifications |
Prof. Andrea RENTMEISTER (UNIVERSITY OF MÜNSTER, Münster, Germany) |
10:00 | Coffee Break and Exhibition |
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| Session 9: Modifying Proteins Structures and Functions |
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| Session Chair: |
Dr Gilles GUICHARD (UNIVERSITY OF BORDEAUX, Bordeaux, France) |
10:30 | PL18: Modulating Different Components of the Ubiquitin System with Small Molecules and Cyclic Peptides |
Prof. Ashraf BRIK (TECHNION-ISRAEL INSTITUTE OF TECHNOLOGY, Haifa, Israel) |
11:15 | PL19: Cysteine Arylation to Engineer, Deliver, and Discover Proteins |
Prof. Bradley Lether PENTELUTE (MASSACHUSETTS INSTITUTE OF TECHNOLOGY, Cambridge, MA, United States) |
| Session 10: Pierre Fabre Award Lecture (Sponsored by Pierre Fabre) |
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| Session Chairs: |
Dr Serge GRISONI (CENTRE DE RECHERCHE ET DÉVELOPPEMENT PIERRE FABRE, Toulouse, France) Dr Brigitte LESUR (SCT & INSTITUT DE RECHERCHES SERVIER, Paris, France) |
12:00 | PL20: Pierre Fabre Award Lecture - Click Chemistry with Mesoionics: New Tools for Chemical Biology |
Dr Frédéric TARAN (CEA/SACLAY, Gif-sur-Yvette, France) |
13:00 | Closing Remarks |
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