| Thursday September 5, 2019 |
| 14:15 | Registration |
|
| 15:00 | Welcome and Opening |
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| Session Chair: |
Prof. Emmanouil FOUSTERIS
(UNIVERSITY OF PATRAS, Patras, Greece) |
| 15:05 | KL01 - The Emergence of Antibody-Drug Conjugates (ADCs) as Targeted Cancer Therapies: From Ehrlich's "Magic Bullet" Concept to Calicheamicin γ1I and Mylotarg |
Prof. K.C. NICOLAOU
(RICE UNIVERSITY, Houston, United States) |
| EFMC-YMCS Competition Presentation Session I |
|
| 15:35 | OC01 - Functionalization of Tumour-Targeting Antibodies Via Enzymatic Oxidation of Tyrosine to 1,2-Quinones
Winner of the Young Medicinal Chemist Meeting in The Netherlands |
Mr Jorick BRUINS
(WAGENINGEN UNIVERSITY, WAGENINGEN, The Netherlands) |
| 15:55 | OC02 - Synthetic Small Molecules Interfering with Oncogenic Micrornas for the Induction of Glioblastoma Stem Cells Differentiation
Winner of the Young Medicinal Chemist Meeting in France |
Dr Chloé MAUCORT
(INSTITUTE OF CHEMISTRY OF NICE, Val de Reuil, France) |
| 16:15 | OC03 -New Ruthenium-Cyclopentadienyl Complexes Bearing Biotinylated (Macro)Ligands: Targeting Strategies to Fight Metastatic Breast Cancer
Winner of the Young Medicinal Chemist Meeting in Portugal |
Dr Leonor CORTE-REAL
(CENTRO DE QUÍMICA ESTRUTURAL, Lisboa, Portugal) |
| 16:35 | Flash Poster Presentations (01-10) |
|
| FP01 - A New Life for Diazaborines: the Next Generation of Serine Protease Inhibitors |
Mr Joao ANTONIO
(UNIVERSITY OF LISBON, Lisbon, Portugal) |
| FP02 - From Peptides to Peptidomimetics: Structure-Activity Relationship of a Factor H-Binding Peptide to Modulate Undesired Host Complement Activity |
Dr Clément BECHTLER
(UNIVERSITY OF BASEL, Wuppertal, Germany) |
| FP03 - Matrix Metalloproteinase-12 Inhibitors: Synthesis, Structure-Activity Relationships and Intestinal Absorption of Novel Sugar-Based Biphenylsulfonamide Carboxylates |
Dr Doretta CUFFARO
(UNIVERSITY OF PISA, Pisa, Italy) |
| FP04 - Photophysical Properties and Antiparasitic Activity of Bodipy-Tethered Dinuclear Trithiolato-Bridged Ruthenium(II)-Arene Complexes |
Mrs Oksana DESIATKINA
(UNIVERSITY OF BERN, Bern, Switzerland) |
| FP05 - N-ALKYL L-Iminosugars as Novel Anti-Inflammatory and Anti-Biofilm Tools for Cystic Fibrosis Lung Infections |
Dr Anna ESPOSITO
(UNIVERSITY OF NAPOLI FEDERICO II, Napoli, Italy) |
| FP06 - Design, Synthesis and Biological Evaluation of Novel Substituted Purine Isosters as EGFR Kinase Inhibitors, with Promising Pharmacokinetic Profile and In Vivo Efficacy |
Dr Efthymios-Spyridon GAVRIIL
(NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS, Athens, Greece) |
| FP07 - Metal-Chelating Acetohydroxamic Acids Against Hepatitis C Virus and Flaviviruses |
Ms Erofili GIANNAKOPOULOU
(NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS, Athens, Greece) |
| FP08 - Discovery of Small-Molecule Modulators of 14-3-3 PPIs Via Dynamic Combinatorial Chemistry |
Mr Alwin HARTMAN
(UNIVERSITY OF GRONINGEN, Groningen, The Netherlands) |
| FP09 - Purine Nucleoside Analogs as Highly Potent Leads for the Treatment of Human African Trypanosomiasis |
Dr Fabian HULPIA
(UGENT, Beerse, Belgium) |
| FP10 - Development of Allosteric Inhibitors of ColH Using DCC Strategy |
Dr Jelena KONSTANTINOVIC
(HELMHOLTZ INSTITUTE FOR PHARMACEUTICAL RESEARCH SAARLAND (HIPS), Saarbrücken, Germany) |
| 16:55 | Coffee Break |
|
| EFMC-YMCS Competition Presentation Session II |
|
| Session Chair: |
Dr Kristina GONCHARENKO
(SPIROCHEM AG, Basel, Switzerland) |
| 17:10 | OC04 - Novel Acridine Derivatives as TDP 1 and/or 2 Inhibitors
Winner of the Young Medicinal Chemist Meeting in Greece |
Mrs Maria KARELOU
(NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS, Athens, Greece) |
| 17:30 | OC05 - Discovery of a Novel Chemotype of Non-Acidic, Neutral and Macrocyclic Keap1 Inhibitors
Winner of the Young Medicinal Chemist Meeting in Sweden |
Mr Fabio BEGNINI
(UPPSALA UNIVERSITY, Uppsala, Sweden) |
| 17:50 | OC06 - Directed Evolution of Short Peptides for Selective Detoxification of Lead
Winner of the Young Medicinal Chemist Meeting in Switzerland |
Dr Michal SHOSHAN
(UNIVERSITY OF ZURICH, Zürich, Switzerland) |
| 18:10 | Flash Poster Presentations (11-20) |
|
| FP11 - Identification, Synthesis and Optimization of Inhibitors of the Protein Tyrosine Phosphatase SHP2 |
Dr Yelena MOSTINSKI
(LEIBNIZ-FORSCHUNGSINSTITUT FÜR MOLEKULARE PHARMAKOLOGIE, Rishon LeZion, Israel) |
| FP12 - Multitarget Triazoles: an Innovative Approach for the Treatment of Alzheimer’s Disease |
Ms Vanesa NOZAL GARCIA
(CIB - CSIC, Madrid, Spain) |
| FP13 - TDP-43 Modulation by CDC7 Inhibitors as a Therapeutic Strategy for Amyotrophic Lateral Sclerosis |
Ms Elisa ROJAS
(CIB - CSIC, Madrid, Spain) |
| FP14 - Use of the 4-Hydroxy-Triazole Moiety as a Bioisosteric Tool in the Development of Selective Ligands for Subtypes Ampa Receptor |
Dr Stefano SAINAS
(UNIVERSITY OF TORINO, Torino, Italy) |
| FP15 - In Vitro and In Ovo Evaluation of Ros-Activatable Anticancer Boronate Prodrugs of Doxorubicin |
Dr Charles SKARBEK
(UNIVERSITY PARIS SUD, Orsay, France) |
| FP16 - Design and Synthesis of Tead's Ligands for the Treatment of Cancers |
Mrs Manon STURBAUT
(UNIVERSITY OF LILLE, Lille, France) |
| FP17 - Drug-Fragment Based Explorations for Novel Enterovirus Inhibitors |
Ms Clara VAN HOEY
(UNIVERSITY OF VIENNA, Vienna, Austria) |
| FP18 - Gemcitabine-GnRH Bioconjugates Bearing Oxime Bond Linkages: Synthesis, In Vitro Stability, Drug Release and Cytotoxic Effect |
Dr Eirinaios VRETTOS
(UNIVERSITY OF IOANNINA, Ioannina, Greece) |
| FP19 - Development of GSTO1-1 Inhibitors for the Treatment of Inflammatory Conditions |
Ms Yiyue XIE
(MONASH UNIVERSITY, Melbourne, Australia) |
| FP20 - Identification of a Novel Quinoline-Based DNA Demethylating Compound Highly Potent in Cancer Cells |
Dr Clemens ZWERGEL
(SAPIENZA UNIVERSITY OF ROME, Rome, Italy) |
| 18:30 | EFMC-YMCS Poster Presentation Session 1 (Odd), Bites & Drinks |
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| 19:30 | EFMC-YMCS Poster Presentation Session 2 (Even), Bites & Drinks |
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| 20:30 | End of the Scientifc Programme |
|
| EFMC-YSN Soft Skills Training Session (1) |
|
| 20:30 | How to Boost Your Oral Presentation Skill, and Create a Good Slideshow |
Dr Kristina GONCHARENKO
(SPIROCHEM AG, Basel, Switzerland) |
| 20:45 | Getting the Job You Deserve! |
Dr. David ALKER
(DAVID ALKER ASSOCIATES, Birchington, United Kingdom) |
| 21:15 | EFMC-YSN Networking Event |
|
| 22:30 | End of the Day |
|
| Friday September 6, 2019 |
| 08:29 | EFMC-YMCS Competition Presentation Session III |
|
| Session Chair: |
Dr Cassandra LEE FLEMING
(UNIVERSITY OF GOTHENBURG, Gothenburg, Sweden) |
| 08:30 | KL02 - Medicinal Chemistry Between Serendipity and (Artificial) Intelligence |
Dr Cornelia ZUMBRUNN
(IDORSIA PHARMACEUTICALS, Allschwil, Switzerland) |
| 09:00 | OC07 - Antiplasmodial Activity of SAHAquines, Novel SAHA - Primaquine Hybrids
Winner of the Young Medicinal Chemist Meeting in Croatia |
Dr Maja BEUS
(UNIVERSITY OF ZAGREB, Durham, United States) |
| 09:20 | OC08 - Hybrdization Approach Towards Novel Antituberculars: Design, Synthesis, And Antimicrobial Evaluation Hybrid Compounds Combining Pyrazinamide and p Aminosalicylic Acid
Winner of the Young Medicinal Chemist Meeting in Czech Republic |
Dr Ghada BOUZ
(CHARLES UNIVERSITY, Hradec Kralove, Czech Republic) |
| 09:40 | OC09 - Synthesis, Computational and Biological Evaluation of Novel Benzimidazole Compounds for the Treatment of Cryptococcus Neoformans
Winner of the Young Medicinal Chemist Meeting in the United Kingdom |
Ms Gina WASHBOURN
(UNIVERSITY OF LIVERPOOL, Liverpool, United Kingdom) |
| 10:00 | OC10 - Nʼ-Benzylated Derivatives of N-(7-Chloroquinolin-4-Yl)Octane-1,8-Diamine as Quorum Sensing Inhibitors in Pseudomonas Aeruginosa
Winner of the Young Medicinal Chemist Meeting in Serbia |
Ms Marta SPASIC
(UNIVERSITY OF BELGRADE, Nis, Serbia) |
| 10:20 | Coffee Break |
|
| EFMC-YMCS Competition Presentation Session IV |
|
| Session Chair: |
Dr Eleni PONTIKI
(ARISTOTELE UNIVERSITY OF THESSALONIKI, Thessaloniki, Greece) |
| 10:40 | OC11 - Geometric Isomers of N-Propargyl-4-Syrylpiperidine Discriminate Between Monoamine Oxidase Isoforms A and B
Winner of the Young Medicinal Chemist Meeting in Slovenia |
Dr Damijan KNEZ
(UNIVERSITY OF LJUBLJANA, Ljubljana, Slovenia) |
| 11:00 | OC12 A Fusing Strategy Application: Towards Potent ChE Inhibitors With MTDL Profile
Winner of the Young Medicinal Chemist Meeting in Turkey |
Dr Gülsah BAYRAKTAR
(EGE UNIVERSITY FACULTY OF PHARMACY, Izmir, Turkey) |
| 11:20 | OC13 - Development of Unique Molecular Probes: Low-Basicity Agonists for the Study of 5-HT7 Receptor Function
Winner of the Young Medicinal Chemist Meeting in Poland |
Dr Adam HOGENDORF
(MAJ INSTITUTE OF PHARMACOLOGY, POLISH ACADEMY OF SCIENCES, Krakow, Poland) |
| 11:40 | OC14 - The Establishment of Tocopherol Reference Intervals for Hungarian Adult Population Using Validated HPLC Method
Winner of the Young Medicinal Chemist Meeting in Hungary
|
Dr Gábor VERES
(HUNGARIAN ACADEMY OF SCIENCES, Budapest, Hungary) |
| 12:00 | Lunch |
|
| EFMC-YSN Soft Skills Training Session (2) |
|
| 13:00 | Why Was My Paper Rejected? Tips from an Editor on How to Get Published |
Dr David PERALTA
(WILEY-VCH VERLAG GMBH & CO. KGAA, Weinheim, Germany) |
| EFMC-YMCS Competition Presentation Session V |
|
| 13:45 | Session Chair: |
Prof. Grigorios ZOIDIS
(UNIVERSITY OF ATHENS, Athens, Greece) |
| 13:45 | OC15 - Expanding the Chemical Space of DNA-Encoded Small Molecule Libraries
Winner of the Young Medicinal Chemist Meeting in Germany |
Dr Andreas BRUNSCHWEIGER
(TU DORTMUND, Dortmund, Germany) |
| 14:05 | OC16 - Finding the Right Candidate for the Right Position: a Fast NMR-Assisted Combinatorial Method for Optimizing Nucleic Acids Binders
Winner of the Young Medicinal Chemist Meeting in Spain |
Dr Andrés GONZALEZ SANTANA
(IQOG - CSIC, Madrid, Spain) |
| 14:25 | OC17 - From ZINC to ZINClick: Our Way to Explore the Chemical Space
Winner of the Young Medicinal Chemist Meeting in Italy |
Prof. Alberto MASSAROTTI
(UNIVERSITY OF EASTERN PIEDMONT, Novara, Italy) |
| 14:45 | OC18 - Extended Glucuronides: Achieving Site-Selectivity Through Extracellular Drug Release
Winner of the Young Medicinal Chemist Meeting in Denmark |
Mr Raoul WALTHER
(AARHUS UNIVERSITY, Aarhus, Denmark) |
| 15:05 | OC19 - Cyclopropenium-Based Polymers
Winner of the Young Medicinal Chemist Meeting in Israel |
Mr Noam STEINMAN
(HEBREW UNIVERSITY OF JERUSALEM, Jerusalem, Israel) |
| 15:25 | Voting Break |
|
| 15:40 | KL03 - Chemical Tools to Target and Image Tumours |
Prof. Stuart CONWAY (UNIVERSITY OF OXFORD, Los Angeles, United States)
(BIOIBÉRICA) |
| 16:10 | Closing and Award Ceremony |
|
| 16:20 | End of the Symposium |
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