| Sunday May 8, 2022 |
| 17:00 | Registration |
|
| 19:00 | Dinner and Get Together |
|
| Monday May 9, 2022 |
| 07:30 | Breakfast |
|
| 08:30 | Opening |
|
| 09:00 | General Introduction to GPCRs: Pharma Relevance, Indications, Molecular Pharmacology |
Prof. Rob LEURS
(VRIJE UNIVERSITEIT AMSTERDAM, Amsterdam, The Netherlands) |
| 10:30 | Coffee Break |
|
| 11:00 | Structural Biology of GPCRs in the Era of Cryo-EM – Implications for Drug Design and Discovery |
Dr Moran SHALEV-BENAMI
(WEIZMANN INSTITUTE, Rehovot, Israel) |
| 12:30 | Lunch |
|
| 14:00 | GPCR Ligands: Molecular Recognition, Kinetics and Allosteric Modulation |
Prof. Laura HEITMAN
(UNIVERSITY OF LEIDEN, Leiden, The Netherlands) |
| 15:30 | Coffee Break |
|
| 16:00 | Partial Agonism/Biased Signalling and its Therapeutical Relevance |
Dr Rob LANE
(UNIVERSITY OF NOTTINGHAM, Nottingham, United Kingdom) |
| 17:30 | Day End
|
|
| 18:00 | Walking tour through Leiden
|
|
| 19:00 | Dinner in Leiden |
|
| Tuesday May 10, 2022 |
| 07:30 | Breakfast |
|
| 08:30 | A General Introduction into GPCRdb & Hands-on with the GPCRdb
|
Dr Albert KOOISTRA
(UNIVERSITY OF COPENHAGEN, København, Denmark) |
| 10:30 | Coffee Break |
|
| 11:00 | System Biology Approaches to GPCR Targets |
Dr Aurelien RIZK
(INTERAX BIOTECH, Villigen, Switzerland) |
| 12:30 | Lunch |
|
| 14:00 | GPCR Ligand Design: Cheminformatics and Modelling |
Dr Chris DE GRAAF
(SOSEI HEPTARES, Cambridge, United Kingdom) |
| 15:30 | Coffee Break |
|
| 16:00 | Tutorials and Excercises |
Dr Chris DE GRAAF (SOSEI HEPTARES, Cambridge, United Kingdom)
Dr Albert KOOISTRA (UNIVERSITY OF COPENHAGEN, København, Denmark) |
| 18:30 | Day End
|
|
| 19:00 | Dinner and Get Together |
|
| Wednesday May 11, 2022 |
| 07:30 | Breakfast |
|
| 08:30 | Discovery of Cariprazine, A Dopamine D3 Receptor Prefering Third Generation Antipsychotics |
Prof. György KESERU
(HUNGARIAN ACADEMY OF SCIENCES, Budapest, Hungary) |
| 09:30 | Discovery of H1/H4 Dual Ligands |
Prof. Iwan DE ESCH
(VU AMSTERDAM, Amsterdam, The Netherlands) |
| 10:30 | Coffee break |
|
| 11:00 | Binding and Modulating GPCRs by Inside/Outside Binding Nanobodies |
Dr Raimond HEUKERS
(QVQ, Utrecht, The Netherlands) |
| 12:30 | Wrap up and Lunch |
|
