3rd EFMC Young Medicinal Chemists' Symposium
Manchester, UK September 1-2, 2016
Registration
Welcome and opening
Session Chair
Case Histories of Fragment-Based Drug Discovery.
Heterocycles and Medicinal Chemistry: the Importance of Innovative Synthesis
New Avenues in Protein Labeling - Exploiting Dna for Directing Chemical Reactions
Winner of the young medicinal chemist meeting in Denmark (CP01)
Drug Design, Synthesis and Biological Evaluation of Antiretroviral and Anticancer Agents
Winner of the young medicinal chemist meeting in Italy (CP02)
Development of Potent, Cell-Active Inhibitors of the Mycobacterium Tuberculosis Cholesterol Oxidase Cyp125 (OC01)
Flash Poster Presentations
FP01- Toward Libraries of Artificial Macrocycles
FP02 - Discovery, Structural Exploration and Biological Profiling of a Novel Class of Antimycobacterial Dpre1 Inhibitors
FP03 - Orally Bioavailable Antimalarial 4(1h)-Quinolone Prodrugs with Single-Dose Cures
FP04 - Developement of Synthesis Methodology for Dna-Encoded Small Molecule Screening Libraries
FP05 - Fishing for an Off-Target": Deconvoluting the Molecular Mechanism of Gpcr-Induced Macrophage Chemotaxis"
FP06 - Design, Synthesis and Pharmacological Evaluation of Fluorescent Tools for Studying Cannabinoid Type 2 Receptor
FP07 - Development of Novel, Selective and Irreversible Pi3kδ Inhibitors
FP08 - Identification of Novel Non-Natural Supramolecular Ligands as Stabilizers of 14-3-3? Protein-Protein Interactions
FP09 - Targets in Orphan Diseases and Their Repurposing Candidates - Analysis with a Knime Workflow Using Open Phacts
FP10 - Selectivity Profiling of the Human Monoamine Transporters: A Case Study on Cathinone Analogs
FP11 - Photoswitchable 4-(Piperidin-4-Yl)-1-Hydroxypyrazole Analogues for the Gaba Type A Receptors
FP12 - Extending Sar of Bile Acids as Fxr/Tgr5 Modulators: Synthesis and Biological Activity of Ring C Modified Cdca Derivatives
FP13 - Lead Optimisation of a Novel Class of Trypanosomacidal Agents
FP14 - Synthesis and Biological Evaluation of Diaromatic Guanidinium-Like Derivatives as Protein Kinase Inhibitors for the Treatment of Cancer
FP15 - Development of Novel 1,4-Benzodiazepines as Antitrypanosomal Agents
FP16 - Determining the Binding Mode of 3-(1-Alkyl-1h-Imidazol-5-Yl)-1h-Indoles
FP17 - Targeting the Human Dihydroorotate Dehydrogenase (Hdhodh) by a Scaffold Hopping Bioisosteric Approach Using Hydroxylated Pentaatomic Heterocycles
FP18 - Towards the Elucidation of the Mechanism of Action of Small Molecule Upregulators of Utrophin Using Chemical Proteomics
FP19 - Development of an Albumin-Binding Ligand for Prolonging the Plasma Half-Life of Peptide Therapeutics
FP20 - Near-Infrared (Nir) Photothermal Therapy Using Biocompatible Palladium Nanoparticles
YMCS Poster presentation session & Networking drink
End of the day
Antimalarial Drug Discovery: Exploring the Mep Pathway
Winner of the young medicinal chemist meeting in the United Kingdom (CP03)
Drugging the Undrugguble: Targeting Challenging E3 Ligases
Winner of the young medicinal chemist meeting in Spain (CP04)
Development of Highly Selective and Reversible Diacylglycerol Lipase Inhibitors
Winner of the young medicinal chemist meeting in The Netherlands (CP05)
Functional Lipidomics-Based Lead Discovery Reveals Novel Role of Phospholipids in Vitamin A Signaling
Winner of the young medicinal chemist meeting in Germany (CP06)
Design, Synthesis and Biological Evaluation of Selective CDK Inhibitors based on Flavopiridol Structure
Winner of the young medicinal chemist meeting in Greece (CP07)
Coffee break
Design and Synthesis of 2,2'-Diindolylmethanes to Selectively Target Certain G-Quadruplex Dna Structures
Winner of the young medicinal chemist meeting in Sweden (CP08)
Stable, Effective, and Selective Anticancer Phenolato Titanium(Iv) Complexes
Winner of the young medicinal chemist meeting in Israel (CP09)
Glyco-Conjugated Photosensitizers: From Synthesis to Validation in Cancer Photodynamic Therapy
Winner of the young medicinal chemist meeting in Portugal (CP10)
Discovery of Cct251921: A Potent, Selective and Orally Bioavailable Small Molecule Modulator of the Mediator Complex-Associated Kinases Cdk8 and Cdk19 (OC02)
Lunch
How to Design Cell Permeable Non-Peptidic Macrocycles (OC03)
New 3d-Scaffolds for Fragment-Based Lead Discovery (Fbld): Exploration of Chemical Space Using Functionalized Spirohydantoins
Winner of the young medicinal chemist meeting in France (CP11)
Discovery Of Novel Atpase Inhibitors Of Dna Gyrase And Topoisomerase Iv Starting From Marine Sponge Alkaloid Oroidin
Winner of the young medicinal chemist meeting in Slovenia (CP12)
Purine Mimicking 3'-Ethynylribofuranose Nucleosides: New Opportunities for an Old Sugar Modification
Winner of the young medicinal chemist meeting in Belgium (KVCV) (CP13)
Experimental Platform for Characterization and High-Throughput Screening of Acetylcholinesterase Inhibitors
Winner of the young medicinal chemist meeting in Poland (CP14)
Novel Derivatives of the Tspo Ligand Dpa-714 For in Vivo Pet Imaging of Neuroinflammation (OC04)
Voting Break
Closing and award ceremony