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| Confirmed Plenary Speakers (to Date) |
| Confirmed Speakers |
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| Sunday April 23, 2023 |
| 17:30 | Registration |
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| 19:30 | Dinner at the Hotel |
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| 21:00 | Get Together at the Castle Bar |
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| Monday April 24, 2023 |
| 07:15 | Breakfast |
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| Opening |
| 08:15 | Opening Ceremony |
Prof. Laura HEITMAN
(UNIVERSITY OF LEIDEN, Leiden, The Netherlands) |
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| Session 1: Introduction to Small Molecule Degraders: PROTACS and Molecular Glues |
| 08:30 | Introduction to Small Molecule Degraders: PROTACS and Molecular Glues - Part 1 |
Prof. Alessio CIULLI (UNIVERSITY OF DUNDEE, Dundee, United Kingdom)
Dr Suzanne O'CONNOR (UNIVERSITY OF DUNDEE, Dundee, United Kingdom) |
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| 10:30 | Introduction to Small Molecule Degraders: PROTACS and Molecular Glues - Part 2 |
Prof. Alessio CIULLI (UNIVERSITY OF DUNDEE, Dundee, United Kingdom)
Dr Suzanne O'CONNOR (UNIVERSITY OF DUNDEE, Dundee, United Kingdom) |
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| 10:00 | Coffee Break |
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| 12:00 | Lunch |
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| Session 2: The Ternary Complex E3-Degrader-Target: Biophysical Binding Assays and Structures |
| 13:30 | The Ternary Complex E3-Degrader-Target: Biophysical Binding Assays and Structures - Part 1 |
Dr Chun-wa CHUNG
(GLAXOSMITHKLINE, Stevenage, United Kingdom) |
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| 15:30 | The Ternary Complex E3-Degrader-Target: Biophysical Binding Assays and Structures - Part 2 |
Dr Chun-wa CHUNG
(GLAXOSMITHKLINE, Stevenage, United Kingdom) |
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| 15:00 | Coffee Break |
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| 17:00 | Day End |
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| 18:00 | Walking Tour through Leiden |
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| 19:30 | Dinner in Leiden |
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| Tuesday April 25, 2023 |
| Session 3: Degrader Probes & Protein Degraders |
| 08:30 | Quality Criteria for Degrader Probes |
Dr Ingo HARTUNG
(MERCK HEALTHCARE, Darmstadt, Germany) |
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| 10:30 | Clinical Aspects of Small Molecule Protein Degraders |
Dr Ingo HARTUNG
(MERCK HEALTHCARE, Darmstadt, Germany) |
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| 10:00 | Coffee Break |
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| 12:00 | Lunch |
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| Session 4: Medicinal Chemistry Optimisation of Small Molecule Degraders |
| 13:30 | Medicinal Chemistry Optimisation of Small Molecule Degraders - Part 1 |
Dr Andrea TESTA
(AMPHISTA THERAPEUTICS, Cambridge, United Kingdom) |
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| 15:30 | Medicinal Chemistry Optimisation of Small Molecule Degraders - Part 2 |
Dr Andrea TESTA
(AMPHISTA THERAPEUTICS, Cambridge, United Kingdom) |
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| 15:00 | Coffee Break |
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| 17:00 | Day End |
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| 19:30 | Dinner at the hotel |
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| 21:00 | Get Together at the Castle Bar |
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| Wednesday April 26, 2023 |
| 07:00 | Breakfast |
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| Session 5: Importance of Cellular Degradation Kinetics and Mechanisms for Development of Potent Therapeutic Degraders |
| 08:30 | Importance of Cellular Degradation Kinetics and Mechanisms for Development of Potent Therapeutic Degraders - Part 1 |
Dr Danette DANIELS
(FOGHORN THERAPEUTICS, Cambridge, United States) |
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| 10:30 | Importance of Cellular Degradation Kinetics and Mechanisms for Development of Potent Therapeutic Degraders - Part 2 |
Dr Danette DANIELS
(FOGHORN THERAPEUTICS, Cambridge, United States) |
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| 10:00 | Coffee Break |
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| 12:00 | Wrap up and Lunch |
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