| Tuesday October 11, 2022 |
| 13:00 | Registration |
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| 14:00 | Workshops (subject to prior registration) |
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| Workshop 1 | Workshop 2 |
| Room 5, 1st floor | Room 3, 1st floor |
| 14:00 | Continuous Chromatography for Small Molecules: Principle, Process Development and Large Scale Manufacturing |
Dr Olivier DAPREMONT
(SK PHARMTECO, Rancho Cordova, United States) |
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| 14:00 | Introduction to Machine-Learning Methods for Process Development. From Multivariate Analysis to Hybrid Models |
Dr Alessandro BUTTE
(DATAHOW, Zurich, Switzerland) |
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| 15:30 | Coffee break |
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| Workshop 3 | Workshop 4 |
| Room 5, 1st floor | Room 3, 1st floor |
| 16:00 | Prep Chiral and Achiral SFC:
Principles and Applications
|
Dr Eric FRANCOTTE (FRANCOTTECONSULTING, Nuglar, Switzerland)
Dr Gerard ROSSE (PIC SOLUTION, San Diego, United States) |
|
| 16:00 | Application of Machine-Learning Methods to the Production of Therapeutic Proteins |
Prof. Massimo MORBIDELLI
(POLITECNICO MILANO, Thessaloniki, Greece) |
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| 17:45 | Welcome Reception sponsored by SK pharmteco |
|
| Ground floor |
| 19:00 | End of the Day |
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| Wednesday October 12, 2022 |
| 08:00 | Registration |
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| 08:30 | Opening Ceremony
|
Prof. José Paulo MOTA
(UNIVERSIDADE NOVA DE LISBOA, Caparica, Portugal) |
| Auditorium II & Overflow Auditorium III |
| Session 1: Modeling and Theory
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| Auditorium II & Overflow Auditorium III |
| 08:40 | Introduction by session chair
|
Prof. Massimo MORBIDELLI
(POLITECNICO MILANO, Thessaloniki, Greece) |
| 08:45 | Measurement of Separation Materials to Enable Mechanistic Modelling and Rational Design (KL01) |
Prof. Dan BRACEWELL
(UNIVERSITY COLLEGE LONDON, London, United Kingdom) |
| 09:25 | Models in the SMB and SMBR Process Development (IL01) |
Dr Damien LEINEKUGEL LE COCQ
(IFP ENERGIES NOUVELLES, Solaize, France) |
| 09:50 | Development of Preparative Chromatographic Processes for the Classification of Nanoparticles (OC01) |
Prof. Malte KASPEREIT
(FRIEDRICH-ALEXANDER-UNIVERSITÄT ERLANGEN-NÜRNBERG, Erlangen, Germany) |
| 10:10 | Optimizing AAV Full/Empty Separation Using Mechanistic Modeling (OC02) |
Dr Tatjana TRUNZER
(CYTIVA, Karlsruhe, Germany) |
| 10:30 | Coffee break & Exhibiton
|
|
| Ground floor |
| Session 2: Biomolecules I
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| Auditorium II & Overflow Auditorium III |
| 11:00 | Introduction by session chair
|
Prof. Andreas SEIDEL-MORGENSTERN
(MAX PLANCK INSTITUTE FOR DYNAMICS OF COMPLEX TECHNICAL SYSTEMS, Magdeburg, Germany) |
| 11:05 | Proteins at Chromatographic Surfaces – Competitive Binding and On-column Aggregate Formation on Monomodal and Multimodal Anion Exchangers (KL02) |
Prof. Giorgio CARTA
(UNIVERSITY OF VIRGINIA, Charlottesville, United States) |
| 11:45 | Protein Purification Using Magnetic Adsorbents and Magnetic Separation - a Robust Alternative to Conventional Chromatography? (IL02) |
Prof. Mathias FRANZREB
(KARLSRUHE INSTITUTE OF TECHNOLOGY, Karlsruhe, Germany) |
| 12:10 | Intensified Purification of Monoclonal Antibodies with Double Flow-Through Membrane Chromatography (OC03) |
Mr Fabian SCHMITZ
(SARTORIUS STEDIM BIOTECH GMBH, Göttingen, Germany) |
| 12:30 | Coupling Preferential Precipitation and IEX for Reducing Acidic Variant Content in Monoclonal Antibody Pools (OC04) |
Prof. Dorota ANTOS
(RZESZOW UNIVERSITY OF TECHNOLOGY, Rzeszow, Poland) |
| 12:50 | Lunch break & Exhibition until 14:05
|
|
| Ground floor |
| Vendor Seminar 1 | Vendor Seminar 2 | Vendor Seminar 3 |
| Room 2, 1st floor | Room 5, 1st floor | Room 3, 1st floor |
| 13:00 | Nouryon / Kromasil Seminar
Chromatographic toolbox for Purification of GLP-1 Agonist and Advances in the Development of Stationary Phases and Purifications in Preparative Chromatography |
|
|
| 13:00 | Osaka Soda Co., Ltd. Seminar
You need a COMPASS! |
|
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| 13:00 | Sartorius Seminar
Chromatography challenges to purify Oligonucleotides and mRNA: how to deal with aggressive buffer and high temperature? |
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| Session 3: Biomolecules II
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| Auditorium II & Overflow Auditorium III |
| 14:05 | Introduction by session chair
|
Dr Michael SCHULTE
(MERCK KGAA, Darmstadt, Germany) |
| 14:10 | Process Scale MCSGP Purification of large Synthetic Molecules (KL03) |
Dr Ralf EISENHUTH
(BACHEM, Bubendorf, Switzerland) |
| 14:50 | Making Affinity Chromatography an Integral Part of Vaccine Development and Manufacturing (IL03) |
Dr Mikkel NISSUM
(GSK, Siena, Italy) |
| 15:15 | Integration of Chromatography and Allied Separation Technologies Towards Autonomous Continuous MRNA Production (OC05) |
Dr Axel SCHMIDT
(INSTITUT FÜR THERMISCHE VERFAHRENSTECHNIK, TUC, Clausthal-Zellerfeld, Germany) |
| 15:35 | Continuous Purification of Virus-Based Biologics Using Periodic Counter-Current Chromatography (OC06) |
Dr Ricardo SILVA
(IBET, Oeiras, Portugal) |
| 15:55 | Coffee break
|
|
| Ground floor |
| Session 4: Small Molecules
|
|
| Auditorium II & Overflow Auditorium III |
| 16:25 | Introduction by session chair
|
Dr Olivier DAPREMONT
(SK PHARMTECO, Rancho Cordova, United States) |
| 16:30 | The Evolution of Chromatographic Processes for Small Molecules Between Research and Production of APIs (KL04) |
Dr Gunnar GARKE
(BAYER AG, Wuppertal, Germany) |
| 17:10 | Large Scale SFC to Enable Delivery of Candidate Drugs; Cost Savings, Sustainability and Fundamental Learnings (IL04) |
Dr Hanna LEEK
(ASTRAZENECA R&D, Mölndal, Sweden) |
| 17:35 | Fixed-Bed and Simulated Moving Bed Chromatography Using Achiral and Chiral Adsorbents for the Complete Preparative Separation of a Quaternary Mixture (OC07) |
Mr Rami ARAFAH
(POLYTECHNIC INSTITUTE OF BRAGANÇA, Braganca, Portugal) |
| 17:55 | High-Throughput Analytical and Purification Capabilities at Janssen Research and Development, Toledo (OC08) |
Dr Alberto FONTANA
(JANSSEN, Toledo, Spain) |
| 18:15 | Poster Session 1 sponsored by Cytiva & Networking
|
|
| Foyer 1st floor |
| 19:15 | End of the Day |
|
| Thursday October 13, 2022 |
| Session 5: Pharmaceutical Industry
|
|
| Auditorium II & Overflow Auditorium III |
| 09:10 | Introduction by session chair
|
Dr Pilar FRANCO
(CHIRAL TECHNOLOGIES EUROPE, Illkirch, France) |
| 09:15 | Preparative Separation by Chromatography from Laboratory to Industrial Scale in a Pharmaceutical Environment Applied to Small Molecules (IL05) |
Dr Antoni SEVERINO
(UCB, Braine-l'Alleud, Belgium) |
| 09:40 | New Purification Strategy of Polyether Block Copolymers by Means of Simulated Moving Bed Size Exclusion Chromatography (OC09) |
Dr Pedro SÁ GOMES
(BASF SE, Ludwigshafen am Rhein, Germany) |
| 10:00 | New Approaches in Preparative Chromatography for Lipid Nanoparticle (LNP) Building Blocks (OC10) |
Dr Markus JUZA
(CORDEN PHARMA SWITZERLAND, Liestal, Switzerland) |
| 10:20 | Coffee break & Exhibition
|
|
| Ground floor |
| Session 6: Automation and Simulation
|
|
| Auditorium II & Overflow Auditorium III |
| 10:50 | Introduction by session chair
|
Dr Alessandro BUTTE
(DATAHOW, Zurich, Switzerland) |
| 10:55 | Automation and Digitalization in the Manufacturing of Therapeutic Proteins (KL06) |
Prof. Massimo MORBIDELLI
(POLITECNICO MILANO, Thessaloniki, Greece) |
| 11:35 | Strategies and Emerging Technologies for Downstream Purification (IL06) |
Dr Gunnar MALMQUIST
(CYTIVA, Uppsala, Sweden) |
| 12:00 | General Bio-Chromatographic Digital Twin in Quality-By-Design Based Process Design and Machine-Learning Based Process Control (OC11) |
Mr Florian VETTER
(TU CLAUSTHAL, Clausthal-Zellerfeld, Germany) |
| 12:20 | Hybrid Models for the Simulation and Prediction of Chromatographic Processes (OC12) |
Dr Alessandro BUTTE
(DATAHOW, Zurich, Switzerland) |
| 12:40 | Lunch break & Exhibition until 13:55 |
|
| Gound floor |
| Vendor Seminar 4 | Vendor Seminar 5 | Vendor Seminar 6 |
| Room 2, 1st floor | Room 5, 1st floor | Room 3, 1st floor |
| 12:50 | Tosoh Bioscience Seminar
Multi-column chromatography – A powerful tool to enhance productivity in downstream processing |
|
|
| 12:50 | RotaChrom Technologies LLC Seminar
CPC Simulator – Accelerating Method Development in Centrifugal Partition Chromatography |
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| 12:50 | De Dietrich & Thar Process Seminar
Sustainable API/Excipient Purification : After Years of Success in Discovery Laboratories, SFC is Finally Emerging as a Manufacturing Technique |
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| Session 7: Continuous Chromatography
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| Auditorium II & Overflow Auditorium III |
| 13:55 | Introduction by session chair
|
Dr Lars AUMANN
(CHROMACON AG, Zürich, Switzerland) |
| 14:00 | Cyclic Adsorption Processes. What else? (KL07) |
Prof. Alirio RODRIGUES
(UNIVERSITY OF PORTO, Porto, Portugal) |
| 14:40 | Chromatography in Colour – Application of Processes Chromatography to the Efficient Recycling of Critical Metals (IL07) |
Dr Paul O'SHAUGHNESSY
(JOHNSON MATTHEY, Oxfordshire, United Kingdom) |
| 15:05 | Continuous Size Fractionation of Nanoparticles for Biomedical Purposes Using Magnetic Field Controlled SMB (OC13) |
Ms Laura KUGER
(KARLSRUHE INSTITUTE OF TECHNOLOGY (KIT), Eggenstein-Leopoldshafen, Germany) |
| 15:25 | Simulated Moving Bed Chromatography - Mass Spectrometry (SMB-MS): Continuous On-Line Sample Preparation for Process Analytical Technology (OC14) |
Ms Juliane DIEHM
(KARLSRUHE INSTITUTE OF TECHNOLOGY, Karlsruhe, Germany) |
| 15:45 | Coffee break |
|
| Ground floor |
| Session 8: Optimization & Prediction
|
|
| Auditorium II & Overflow Auditorium III |
| 16:15 | Introduction by session chair
|
Prof. Dorota ANTOS
(RZESZOW UNIVERSITY OF TECHNOLOGY, Rzeszow, Poland) |
| 16:20 | What is the Right Level of Purity? Benefits of Overpurifying and Underpurifying in Chromatography (KL08) |
Prof. Tuomo SAINIO
(LAPPEENRANTA UNIVERSITY OF TECHNOLOGY, Lappeenranta, Finland) |
| 17:00 | Exploring Enhanced Selectivity of Mixed Mode Cation Exchange Resins in Bispecific and Complex Immunoglobulin Purification (IL08) |
Mr Wolfgang KOEHNLEIN
(F. HOFFMANN-LA ROCHE, Penzberg, Germany) |
| 17:25 | Short-Cut Design of Four-Zone Simulated Moving Bed Chromatography for Multi-Component Systems: Langmuir-Type Isotherms (OC15) |
Dr Ju Weon LEE
(OTTO VON GUERICKE UNIVERSITY, Magdeburg, Germany) |
| 17:45 | Robustness Analysis by Predictive Distribution for Various Operating Configurations for Simulated Moving Bed Chromatography (OC16) |
Mr Kensuke SUZUKI
(NAGOYA UNIVERSITY, Nagoya, Japan) |
| 18:05 | Poster session 2 sponsored by Cytiva & Networking
|
|
| Foyer 1st floor |
| 19:15 | End of the Day |
|
| 20:30 | Gala dinner at Monte Mar Restaurant, sponsored by Cytiva
(subject to prior registration) |
|
| Friday October 14, 2022 |
| Session 9: SFC & Natural Products
|
|
| Auditorium II & Overflow Auditorium III |
| 08:30 | Introduction by session chair
|
Dr Hanna LEEK
(ASTRAZENECA R&D, Mölndal, Sweden) |
| 08:35 | The Role of CO2 Separation (SFC) in the Eco-Sustainable Production of APIs and Hemp Ingredients (IL09) |
Dr Gerard ROSSE
(PIC SOLUTION, San Diego, United States) |
| 09:00 | The Thar Process Journey Regarding Green Chemistry Application Using Supercritical Carbon Dioxide (IL10) |
Dr Lalit CHORDIA
(THAR PROCESS INC., Pittsburgh, United States) |
| 09:25 | Industral Application of Supercritical Fluid Simulated Moving Bed in the Separation of N-3 Pufa from Fish Oil (OC17) |
Ms Xiaoqing BAO
(JOPE TECHNOLOGY CO., LTD , Kaohsiung, Taiwan) |
| 09:45 | Process Stabilization by Online Monitoring of a Mini-Plant Coupling Enantioselective SMB Chromatography and Enzymatic Racemization (OC18) |
Ms Isabel HARRIEHAUSEN
(MAX-PLANCK-INSTITUTE, Magdeburg, Germany) |
| 10:05 | Study of Liquid-Liquid Chromatography Operation in the Nonlinear Range of the Partition Equilibria (OC19) |
Mrs Melanie GERIGK
(TECHNICAL UNIVERSITY OF MUNICH, Freising, Germany) |
| 10:35 | Coffee break
|
|
| Ground floor |
| Session 10: Biomolecules III
|
|
| Auditorium II & Overflow Auditorium III |
| 11:05 | Introduction by session chair
|
Prof. Malte KASPEREIT
(FRIEDRICH-ALEXANDER-UNIVERSITÄT ERLANGEN-NÜRNBERG, Erlangen, Germany) |
| 11:10 | Progress and Trends of Virus Based Biopharmaceuticals Purification (IL11) |
Dr Cristina PEIXOTO
(IBET, Oeiras, Portugal) |
| 11:35 | Advanced Gradient SMBC Applied to Antibody Purification (OC20) |
Mr Masahiro OGINO
(ORGANO CORPORATION, SAGAMIHARA-shi, Japan) |
| 11:55 | Design and Operation of an Integrated Continuous Downstream Process for Acid-Sensitive Mabs Based on a Calcium-Dependent Protein a Ligand (OC21) |
Prof. Bernt NILSSON
(LUND UNIVERSITY, Lund, Sweden) |
| 12:15 | Protein Separation by Simulated Moving Bed (OC22) |
Ms Albertina RIOS
(UNIVERSITY OF PORTO, Porto, Portugal) |
| 12:35 | Closing |
Prof. José Paulo MOTA
(UNIVERSIDADE NOVA DE LISBOA, Caparica, Portugal) |
